6-Amino-3-butyl-5-nitro-phthalide → 5,6-Diamino-3-butyl-phthalide
反応式
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:12][CH2:13][CH2:14][CH3:15])[O:7][C:8]2=[O:9])=[CH:4][C:3]=1[N+:16]([O-])=O.[H][H]>C(O)C.[Ni]>[NH2:16][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[NH2:1])[C:8](=[O:9])[O:7][CH:6]2[CH2:12][CH2:13][CH2:14][CH3:15]参加物
5
実験手順
To a suspension of 3.75 g (15 mmol) of compound obtained in Example 22 in 150 ml of 95% ethanol there is added Raney nickel catalyst to hydrogenate at a hydrogen pressure of 1 kg/cm2. After the absorption of hydrogen has ceased, the catalyst is filtered off, and the filtrate is concentrated to dryness. The residue is crystallised from dilute ethanol, giving the title product.
後処理
- customAfter the absorption of hydrogen
- filtrationthe catalyst is filtered off
- concentrationthe filtrate is concentrated to dryness
- customThe residue is crystallised from dilute ethanol
出典と根拠
- ORDレコード
- ord-4e5c8472d63e408cadda75bf8fb62825
- 出典データセット
- uspto-grants-2004_02
- 特許番号
- US06689808B2
反応ノート
読み込み中…