Piperidine → HCID 69883696、化合物

HRID 2120195

反応式

HRID 2120195 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:15]=[C:14]3[C:10]([CH2:11][C:12](=[O:16])[NH:13]3)=[CH:9][CH:8]=2)[CH:2]=1.[CH3:17][O:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][C:20]=1[C:27]1[S:28][CH:29]=[CH:30][CH:31]=1.N1CCCCC1>C(O)C.CCOCC>[CH3:17][O:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]=[C:11]2[C:10]3[C:14](=[CH:15][C:7]([C:3]4[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=4)=[CH:8][CH:9]=3)[NH:13][C:12]2=[O:16])=[CH:21][C:20]=1[C:27]1[S:28][CH:29]=[CH:30][CH:31]=1

参加物

6

反応物 3

HCID 8082PiperidineHCID 219155796-Pyridin-3-yl-1,3-dihydro-indol-2-oneHCID 219810244-Methoxy-3-(thiophen-2-yl)benzaldehyde

生成物 1

HCID 69883696HCID 69883696、化合物収率 15%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 6-pyridin-3-yl-1,3-dihydro-indol-2-one (100 mg, 0.5 mmol), 4-methoxy-3-thiophen-2-yl-benzaldehyde (110 mg, 0.5 mmol) and piperidine (0.23 mL) in ethanol (4 mL) was heated to reflux and stirred overnight. The reaction mixture was then cooled and diluted with ether to afford a precipitate which removed by filtration. Thefiltrate was column chromatographed (eluant—isopropanol/dichloromethane) to give 30 mg (15%) of 3-(4-methoxy-3-thiophen-2-yl-benzylidene)-6-pyridin-3-yl-1,3-dihydroindol-2-one as a yellow solid.

後処理

  1. temperaturewas heated
  2. temperatureto reflux
  3. temperatureThe reaction mixture was then cooled
  4. customto afford a precipitate which
  5. customremoved by filtration
  6. customThefiltrate was column chromatographed (eluant—isopropanol/dichloromethane)

出典と根拠

ORDレコード
ord-109e72eee4dd4152a9a69a299f59271f
出典データセット
uspto-grants-2004_02
特許番号
US06689806B1

関連ノート

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