Water → 2-(Benzenesulfonyl)acetamide

HRID 2120280ノート

反応式

HRID 2120280 の反応式
Br[CH2:2][C:3]([NH2:5])=[O:4].[C:6]1([S:12]([O:14][Na])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.O>CN(C=O)C>[C:6]1([S:12]([CH2:2][C:3]([NH2:5])=[O:4])(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 696322-BromoacetamideHCID 178527445HCID 178527445、化合物

生成物 1

HCID 18103052-(Benzenesulfonyl)acetamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of α-bromoacetamide IV in anhydrous DMF, is added PhSO2Na at 0° C. The reaction mixture is stirred for 1 hour at room temperature and is then poured into water. The organic layer is washed with brine, dried over Na2SO4, and evaporated. The residue is purified by silica gel column chromatography to give α-phenylsulfonylacetamide III.

後処理

  1. washThe organic layer is washed with brine
  2. dry with materialdried over Na2SO4
  3. customevaporated
  4. customThe residue is purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-65266f6a96dc47279dedb4650eca1c6a
出典データセット
uspto-grants-2004_02
特許番号
US06689890B2

反応ノート

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