Malonic Acid → HCID 54424786、化合物

HRID 2121089

反応式

HRID 2121089 の反応式
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[C:6]([F:12])[CH:5]=1)([O-:3])=[O:2].C(O)(=O)[CH2:14][C:15]([OH:17])=[O:16]>C(O)C>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[CH:14][C:15]([OH:17])=[O:16])=[C:6]([F:12])[CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 867Malonic AcidHCID 45629192-Fluoro-4-nitrobenzaldehyde

生成物 1

HCID 54424786HCID 54424786、化合物収率 90%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A suspension of 4-nitro-2-fluorobenzaldehyde (3.16 g, 18.7 mmol), malonic acid (2.14 g, 21 mmol) pyridine (catalytic) and ethanol (10 mL) was heated to reflux for 6 hours. The suspension became a clear solution upon heating. Upon cooling to room temperature solids formed and were isolated by filtration. The solids were washed with cool (15° C.) ethanol and then with 1N HCl and dried, giving 3.32 g 4-nitro-2-fluorocinnamic acid (90% yield).

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 6 hours
  3. temperatureupon heating
  4. customformed
  5. customwere isolated by filtration
  6. washThe solids were washed
  7. temperaturewith cool (15° C.) ethanol
  8. dry with materialwith 1N HCl and dried

出典と根拠

ORDレコード
ord-e79f8de3f0804c18962f154ca5e0a4c4
出典データセット
uspto-grants-2004_02
特許番号
US06693208B2

関連ノート

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