関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 3-(4-Chloro-3-nitrophenyl)acrylic acid | HCID 614919 | — |
| 触媒 | Platinum sulfide (PtS) | HCID 82861 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-(4-Chloro-3-aminophenyl)propionic acid | HCID 12388282 | 99.8% |
反応手順
A slurry of 4-chloro-3-nitrocinnamic acid (12.2 g, 53.2 mmol), ethyl alcohol (50 mL) and ethyl acetate (20 mL) was treated with 5% Platinum sulfide on carbon (0.6 g) and was placed in a Parr autoclave. The autoclave was placed under a hydrogen atmosphere and heated overnight at 50° C. After cooling to room temperature, the reaction mixture was filtered through celite, and was concentrated in vacuo to yield 10.6 g of 3-(4-chloro-3-aminophenyl)propionic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06693208B2 |
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| 出典データセット | uspto-grants-2004_02 |
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| ORD ID | ord-cdfe74b4c4d9483d86cee73568f571cc |
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| 出典メモ | uspto-grants-2004_02 |
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