Nitrous Acid → Methyl 4-fluoro-2-phenylbenzoate

HRID 2121116ノート

反応式

HRID 2121116 の反応式
N[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:3]=1.N([O-])=O.[Na+].N(O)=O.[H+].[B-](F)(F)(F)[F:27]>>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([F:27])=[CH:3][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 4

HCID 24529Nitrous AcidHCID 28118Tetrafluoroboric acidHCID 154069885-Amino-biphenyl-2-carboxylic acid methyl esterHCID 23668193Sodium Nitrite

生成物 1

HCID 54170746Methyl 4-fluoro-2-phenylbenzoate

実験手順

A solution of methyl 4-amino-2-phenylbenzoate (1.0 equivalent) in dilute aqueous HBF4 is treated with NaNO2 (1.1 equivalents) until an excess of nitrous acid persists. The mixture is extracted into ethyl acetate which is dried and evaporated. The title ester is purified by chromatography on silica gel.

後処理

  1. extractionThe mixture is extracted into ethyl acetate which
  2. customis dried
  3. customevaporated
  4. customThe title ester is purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-a39b611a61e3470b9656c48489b8691f
出典データセット
uspto-grants-2004_02
特許番号
US06693123B2

反応ノート

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