Benzyl Isothiocyanate → 3-Benzyl-1-methyl-2-thioxoimidazolidin-4-one
反応式
Cl.CO[C:4](=[O:8])[CH2:5][NH:6][CH3:7].C1CCN2C(=NCCC2)CC1.[CH2:20]([N:27]=[C:28]=[S:29])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(O)C>[CH2:20]([N:27]1[C:4](=[O:8])[CH2:5][N:6]([CH3:7])[C:28]1=[S:29])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1参加物
5
実験手順
To a solution of sarcosine methyl ester hydrochloride (0.56 g, 4.0 mmol) and DBU (0.60 mL, 4.0 mmol) in anhydrous ethanol added benzyl isothiocyanate (0.53 mL, 4.0 mmol). The resulting solution was heated at reflux 16 h, cooled, concentrated and chromatographed (silica gel, DCM) to give the title compound (0.88 g, quant.). 1H-NMR (CDCl3): δ 7.49-7.53 (2H, m), 7.28-7.35 (3H, m), 5.02 (2H, s), 4.03 (2H, s), 3.34 (3H, s).
後処理
- temperatureThe resulting solution was heated
- temperatureat reflux 16 h
- temperaturecooled
- concentrationconcentrated
- customchromatographed (silica gel, DCM)
出典と根拠
- ORDレコード
- ord-566add14f0be4d398821deabb1b039d8
- 出典データセット
- uspto-grants-2004_02
- 特許番号
- US06696473B2
反応ノート
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