Acetic Anhydride → N-(4-Chloro-3-nitrophenyl)acetamide

HRID 2122010

反応式

HRID 2122010 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:14])[CH3:13])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 124774-Chloro-3-nitroaniline

生成物 1

HCID 79672N-(4-Chloro-3-nitrophenyl)acetamide収率 96.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 4-chloro-3-nitroaniline (17.3 g, 100 mmol) in DCM (150 mL) was added dropwise acetic anhydride (14 mL, 150 mmol) at ambient temperature. The mixture was stirred at ambient temperature for 2.5 h. The solvent was removed in vacuo, and Et2O was added to the residue. The precipitate was collected by filtration, washed with Et2O, and dried in vacuo to give N-(4-chloro-3-nitrophenyl)acetamide (20.7 g, 96%), which was used without further purification.

後処理

  1. customThe solvent was removed in vacuo, and Et2O
  2. additionwas added to the residue
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with Et2O
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-92b72ee7c9184a7282a64c27b1157a3c
出典データセット
uspto-grants-2004_02
特許番号
US06696473B2

関連ノート

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