Triethylamine → 3,4-dichloro-N-(1-methyl-1-phenylethyl)benzamide

HRID 21234

反応式

HRID 21234 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5](Cl)=[O:6].[C:12]([NH2:21])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([CH3:14])[CH3:13].C(N(CC)CC)C>ClCCl.CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([NH:21][C:12]([CH3:14])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH3:13])=[O:6]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 68509CumylamineHCID 76403Benzoyl chloride, 3,4-dichloro-

生成物 1

HCID 130519573,4-dichloro-N-(1-methyl-1-phenylethyl)benzamide収率 88%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

In a similar manner to Step 1 of Example 16, 3,4-dichlorobenzoyl chloride (3.00 g, 14.3 mmol) was dissolved in dichloromethane (60 mL), and the solution was treated with cumylamine (2.30 mL, 15.7 mmol), triethylamine (3.00 mL, 21.5 mmol) and DMAP (175 mg, 1.43 mmol), followed by purification by slurry using chloroform to obtain 3,4-dichloro-N-(1-methyl-1-phenylethyl)benzamide (3.85 g, yield 88%).

後処理

  1. customfollowed by purification by slurry

出典と根拠

ORDレコード
ord-392a4fb00f8148fe8cea8dc5b9d046b0
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

関連ノート

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