Hydrochloride methanol → 4-Chloro-5-hydroxy-7-iodoisoindolinone

HRID 21261

反応式

HRID 21261 の反応式
[Cl:1][C:2]1[C:10]([OH:11])=[CH:9][C:8]([I:12])=[C:7]2[C:3]=1[CH2:4][N:5](C(C)(C1C=CC=CC=1)C)[C:6]2=[O:13].Cl.CO>>[Cl:1][C:2]1[C:10]([OH:11])=[CH:9][C:8]([I:12])=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:13]

参加物

3

反応物 2

HCID 21893726Hydrochloride methanolHCID 684939844-Chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

生成物 1

HCID 684892494-Chloro-5-hydroxy-7-iodoisoindolinone収率 58%

実験手順

In a similar manner to Step 6 of Example 139, 4-chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (97.1 mg, 0.206 mmol) was treated with 10% hydrogen chloride-methanol solution (3 mL), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-hydroxy-7-iodoisoindolinone (36.9 mg, yield 58%).

後処理

  1. customfollowed by purification by slurry

出典と根拠

ORDレコード
ord-9e6bd2567c9c46e48a78b830e9111924
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

関連ノート

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