2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{3-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-phenyl}-pyrimidin-2-ylamine

反応式

[Br:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]([C:24]([F:25])([F:26])[F:27])[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[cH:13]2)[cH:5][cH:6][cH:7]1.[NH2:28][c:29]1[n:30][cH:31][c:32]([B:35]2[O:36][C:37]([CH3:38])([CH3:39])[C:40]([CH3:41])([CH3:42])[O:43]2)[cH:33][n:34]1>>[c:2]1(-[c:32]2[cH:31][n:30][c:29]([NH2:28])[n:34][cH:33]2)[cH:3][c:4](-[c:8]2[n:9][c:10]([C:24]([F:25])([F:26])[F:27])[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]3)[cH:13]2)[cH:5][cH:6][cH:7]1

参加物

反応物 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol ester

HCID 574687952-(3-Bromo-phenyl)-6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine

生成物 1

HCID 602094545-{3-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-phenyl}-pyrimidin-2-ylamine

出典と根拠

ORDレコード: ord-dc7a6da80da94d6084b765b6185968ff
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…