Triethylamine → HCID 86628298、化合物

HRID 21278ノート

反応式

HRID 21278 の反応式
[OH:1][C:2]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[N:13]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C:14]3[C:19]([CH:20]=2)=[CH:18][C:17]([CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:16][CH:15]=3)=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:35].C(N(CC)CC)C.[CH3:43][S:44](Cl)(=[O:46])=[O:45]>ClCCl>[CH3:43][S:44]([O:1][C:2]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[N:13]([C:28]([O:30][C:31]([CH3:32])([CH3:34])[CH3:33])=[O:29])[C:14]3[C:19]([CH:20]=2)=[CH:18][C:17]([CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:16][CH:15]=3)=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:35])(=[O:46])=[O:45]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 684899824-Hydroxy-5-methyl-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

生成物 1

HCID 86628298HCID 86628298、化合物収率 85.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a similar manner to Step 1 of Example 289, 4-hydroxy-5-methyl-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (80.5 mg, 0.170 mmol) was dissolved in dichloromethane (3 mL), and the solution was treated with triethylamine (0.095 mL, 0.68 mmol) and methanesulfonyl chloride (0.026 mL, 0.34 mmol), followed by purification by slurry using hexane to obtain 4-methanesulfonyloxy-5-methyl-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (80.3 mg, yield 85%).

後処理

  1. customfollowed by purification by slurry

出典と根拠

ORDレコード
ord-439c907de8a64e048c5913f20ddf1b66
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

反応ノート

読み込み中…