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Potassium Carbonate → 4-Chloro-5-[4-(tert-butyldimethylsiloxy)butoxy]-7-iodoisoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | tert-Butyl(4-iodobutoxy)dimethylsilane | HCID 4250746 | — |
| 反応物 | 4-Chloro-5-hydroxy-7-iodoisoindolinone | HCID 68489249 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Chloro-5-[4-(tert-butyldimethylsiloxy)butoxy]-7-iodoisoindolinone | HCID 68489186 | 84.1% |
反応手順
In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.0 mg, 0.226 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (93.8 mg, 0.679 mmol) and tert-butyl(4-iodobutoxy)dimethylsilane (0.176 mL, 0.679 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1, 19/1) to obtain 4-chloro-5-[4-(tert-butyldimethylsiloxy)butoxy]-7-iodoisoindolinone (94.2 mg, yield 84%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b55de8f5f3794a9395126dbed7095092 |
| 出典メモ | uspto-grants-2010_06 |