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Sodium hydride → 3-[(2,3-dihydro4,5-diphenyl-2-oxo-1H-imidazol-1-yl)methyl]benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Benzonitrile, 3-(bromomethyl)- | HCID 97249 | — |
| 反応物 | 1,3-Dihydro-4,5-diphenyl-2H-imidazol-2-one | HCID 231587 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-[(2,3-dihydro4,5-diphenyl-2-oxo-1H-imidazol-1-yl)methyl]benzonitrile | HCID 54450135 | — |
反応手順
In a manner similar to Preparation 1 above, 2,3-dihydro-4,5-diphenyl-1H-imidazol-2-one (1.2 g, 5 mmol) was reacted with 3-(bromomethyl)benzonitrile (0.39 g, mmol) and sodium hydride (0.18 g, 5 mmol) in dimethylformamide (20 mL) to give 3-[(2,3-dihydro-4,5-diphenyl-2-oxo-1H-imidazol-1-yl)methyl]benzonitrile after chromatography on silica; NMR (DMSO-d6) 11.02 (s, 1), 7.4 (m,4), 7.3 (m,2), 7.2 (m,7), 4.75 (s,2) ppm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728697 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-aad224480b7f4172a95830c33af130b0 |
| 出典メモ | uspto-grants-1998_03 |