6-chloro-N-[2-(4-methylpiperazin-1-ylmethyl)phenyl]nicotinamide → 6-(5-Cyclopropylcarbamoyl-2-methyl-phenyl)-N-[2-(4-methylpiperazin-1-ylmethyl)phenyl]-nicotinamide

反応式

[CH:25]1([NH:28][C:29]([c:30]2[cH:31][c:32]([B:37]3[O:38][C:39]([CH3:40])([CH3:41])[C:42]([CH3:43])([CH3:44])[O:45]3)[c:33]([CH3:36])[cH:34][cH:35]2)=[O:46])[CH2:26][CH2:27]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[c:10]([CH2:15][N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[cH:11][cH:12][cH:13][cH:14]2)[cH:23][cH:24]1>>[c:2]1(-[c:32]2[cH:31][c:30]([C:29]([NH:28][CH:25]3[CH2:26][CH2:27]3)=[O:46])[cH:35][cH:34][c:33]2[CH3:36])[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[c:10]([CH2:15][N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[cH:11][cH:12][cH:13][cH:14]2)[cH:23][cH:24]1

参加物

反応物 2

HCID 219145746-chloro-N-[2-(4-methylpiperazin-1-ylmethyl)phenyl]nicotinamide

HCID 21914577N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

生成物 1

HCID 219146056-(5-Cyclopropylcarbamoyl-2-methyl-phenyl)-N-[2-(4-methylpiperazin-1-ylmethyl)phenyl]-nicotinamide

出典と根拠

ORDレコード: ord-9d98cb9420a74f9ea0b6f187be755dd6
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…