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Hydrochloric Acid → N-(3-Cyano-4,5,6,7-tetrahydrobenzo(b)thien-2-yl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | 2-Amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carbonitrile | HCID 78382 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-(3-Cyano-4,5,6,7-tetrahydrobenzo(b)thien-2-yl)benzamide | HCID 290221 | 97% |
反応手順
4.7 ml (40 mmol) of benzoyl chloride were added to a solution of 5.34 g (30 mmol) of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene in 50 ml of pyridine. Stirring was carried out for 2 hours at 80° C. after which 150 ml of 10 mol % aqueous hydrochloric acid were added to the mixture. The solid formed was isolated in a conventional manner. Yield: 97%; mp.: 168°-170° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05422335 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-c687d545fb614a2799fe1a2c2fe90189 |
| 出典メモ | uspto-grants-1995_06 |