関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Butyl isocyanate | HCID 8110 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carbonitrile | HCID 78382 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(3-n-Butylureido)-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene | HCID 13742768 | 18% |
反応手順
A mixture of 5.35 g (30 mmol) of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene (prepared according to Intermediate 1e), 2.0 ml (45 mmol) of triethylamine, 10 ml (90 mmol) of n-butyl isocyanate and 100 ml of toluene was stirred for 16 hours at 80° C. The solid formed was then isolated and was recrystallized from ethanol. Yield: 18%; mp.: 170°-171° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05422335 |
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| 出典データセット | uspto-grants-1995_06 |
|---|
| ORD ID | ord-ea64a0b4663547b6a3e35eaa7469e9c7 |
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| 出典メモ | uspto-grants-1995_06 |
|---|
