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Hydrochloric Acid → 4-(Isopropoxymethyl)-pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 生成物 | 4-(Isopropoxymethyl)-pyridine | HCID 14442204 | — |
反応手順
3.4 g of sodium are dissolved in 120 ml of isopropanol and 11 g (0.067 mol) of 4-chloromethylpyridine-hydrochloride are added. The reaction mixture is refluxed for 10 hours under nitrogen, with stirring, then after cooling it is made weakly acidic with dilute hydrochloric acid and concentrated by evaporation under reduced pressure. The residue is made alkaline with 40% potassium carbonate solution and extracted with ether. After drying with anhydrous sodium sulphate the organic phase is concentrated by evaporation. The crude product is then distilled.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05422353 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-9964c7de6933407d9c2220728e01fc8c |
| 出典メモ | uspto-grants-1995_06 |