2-Fluoro-4-chloro-5-cyclopentyloxynitrobenzene → 4-Chloro-5-(cyclopentyloxy)-2-fluorobenzenamine

HRID 21475

反応式

HRID 21475 の反応式
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:4][C:3]=1[N+:15]([O-])=O>C1(C)C=CC=CC=1.[C].[Pd]>[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:4][C:3]=1[NH2:15]

参加物

4

反応物 1

HCID 193744702-Fluoro-4-chloro-5-cyclopentyloxynitrobenzene

生成物 1

HCID 152793894-Chloro-5-(cyclopentyloxy)-2-fluorobenzenamine

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 1140Toluene溶媒

実験手順

The resulting 2-fluoro-4-chloro-5-cyclopentyloxynitrobenzene (13.0 g, 50.1 mmol) was dissolved in toluene (100 ml), a catalytic amount of 10% palladium-carbon (0.5 g) was added thereto, and the mixture was reacted at room temperature to 70° C. under a hydrogen pressure of 3 to 5 atms. in a glass autoclave. After absorption of hydrogen gas ceased, the catalyst was removed by filtration, and the solvent was distilled off under reduced pressure from the filtrate to obtain substantially quantitatively oily 2-fluoro-4-chloro-5-cyclopentyloxyaniline. The spectral data and the like are as described in Reference Example 1.

後処理

  1. customthe mixture was reacted at room temperature to 70° C. under a hydrogen pressure of 3 to 5 atms
  2. customAfter absorption of hydrogen gas
  3. customthe catalyst was removed by filtration
  4. distillationthe solvent was distilled off under reduced pressure from the filtrate

出典と根拠

ORDレコード
ord-67f78207c5b64f1ab0a8cb7a7aad0bee
出典データセット
uspto-grants-1995_06
特許番号
US05424277

関連ノート

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