Dichloromethane → 2-[2-[1-[7-oxo-5-(trifluoromethyl)-6,8-dihydro-5H-pyrido[2,3-d]pyrimidin-4-yl]piperidin-4-yl]-4-(2,2,2-trifluoroethyl)imidazol-1-yl]ethyl methanesulfonate

反応式

[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:42][S:43]([Cl:44])(=[O:45])=[O:46].[Cl:47][CH2:48][Cl:49].[OH:1][CH2:2][CH2:3][n:4]1[c:5]([CH:14]2[CH2:15][CH2:16][N:17]([c:20]3[c:21]4[c:22]([n:23][cH:24][n:25]3)[NH:26][C:27](=[O:34])[CH2:28][CH:29]4[C:30]([F:31])([F:32])[F:33])[CH2:18][CH2:19]2)[n:6][c:7]([CH2:9][C:10]([F:11])([F:12])[F:13])[cH:8]1>>[O:1]([CH2:2][CH2:3][n:4]1[c:5]([CH:14]2[CH2:15][CH2:16][N:17]([c:20]3[c:21]4[c:22]([n:23][cH:24][n:25]3)[NH:26][C:27](=[O:34])[CH2:28][CH:29]4[C:30]([F:31])([F:32])[F:33])[CH2:18][CH2:19]2)[n:6][c:7]([CH2:9][C:10]([F:11])([F:12])[F:13])[cH:8]1)[S:43]([CH3:42])(=[O:45])=[O:46]