Hydrochloric Acid → (5-(R)-(4-aminomethylphenyl)-2,4-dioxoimidazolidin-3-yl)acetic acid hydrochloride

反応式

C(OC([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C@@H:19]([NH:24][C:25]([NH:27][CH2:28][C:29]([O:31]CC)=[O:30])=[O:26])[C:20](OC)=[O:21])=[CH:15][CH:14]=1)=O)C1C=CC=CC=1.[ClH:34]>>[ClH:34].[NH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C@H:19]2[NH:24][C:25](=[O:26])[N:27]([CH2:28][C:29]([OH:31])=[O:30])[C:20]2=[O:21])=[CH:15][CH:14]=1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 67799367HCID 67799367、化合物

生成物 1

HCID 67798814(5-(R)-(4-aminomethylphenyl)-2,4-dioxoimidazolidin-3-yl)acetic acid hydrochloride

実験手順

280 mg of N-(1-(R)-(4-benzyloxycarbonylaminomethylphenyl-1-methoxycarbonylmethyl),N'-ethoxycarbonylmethylurea are boiled under reflux for 45 min in 4 ml of 6N HCl and the mixture is then concentrated and dried over KOH.

後処理

concentrationthe mixture is then concentrated
dry with materialdried over KOH

出典と根拠

ORDレコード: ord-5768d5e45d17463e94180f69eeb44af0
出典データセット: uspto-grants-1995_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05424293

反応ノート

読み込み中…