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3-Amino-1-propanol → N-(3-trifluoromethyl-phenyl)-4-[2-(3-hydroxy-propyl-amino)-4-pyridyl]-2-pyrimidineamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-1-propanol | HCID 9086 | — |
| 反応物 | N-(3-trifluoromethyl-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine | HCID 19689602 | — |
| 生成物 | N-(3-trifluoromethyl-phenyl)-4-[2-(3-hydroxy-propyl-amino)-4-pyridyl]-2-pyrimidineamine | HCID 21948232 | — |
反応手順
50 mg (0.143 mmol) of N-(3-trifluoromethyl-phenyl)-4-(2-chloro4-pyridyl)-2-pyrimidineamine are stirred for 44 h at 100° in 1 ml of 3-amino-1-propanol. Concentration by evaporation and chromatography (methylene chloride:methanol=9:1) give N-(3-trifluoromethyl-phenyl)-4-[2-(3-hydroxy-propyl-amino)-4-pyridyl]-2-pyrimidineamine; Rf =0.1 (methylene chloride:methanol=95:5), FAB-MS: 390, m.p. 158°-163°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728708 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-f35791fc5d9c4277b1f7f4b9129278c8 |
| 出典メモ | uspto-grants-1998_03 |