Ammonia → 9-((4-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecane

反応式

[C:2]([CH3:3])([CH3:4])([CH3:5])[Si:6]([O:7][CH2:8][CH2:9][c:10]1[cH:11][c:12]([CH2:15][N:16]2[CH2:17][CH2:18][C:19]3([CH2:20][N:21]([C:25](=[O:26])[C:27]([F:28])([F:29])[F:30])[CH2:22][CH2:23][O:24]3)[CH2:31][CH2:32]2)[s:13][cH:14]1)([CH3:33])[CH3:34].[CH3:35][OH:36].[NH3:1]>>[C:2]([CH3:3])([CH3:4])([CH3:5])[Si:6]([O:7][CH2:8][CH2:9][c:10]1[cH:11][c:12]([CH2:15][N:16]2[CH2:17][CH2:18][C:19]3([CH2:20][NH:21][CH2:22][CH2:23][O:24]3)[CH2:31][CH2:32]2)[s:13][cH:14]1)([CH3:33])[CH3:34]

参加物

反応物 3

HCID 222Ammonia

HCID 887Methanol

HCID 579892241-(9-((4-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-2,2,2-trifluoroethanone

生成物 1

HCID 579891139-((4-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecane

出典と根拠

ORDレコード: ord-5d67701fde5944679345444e87f3426e
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…