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Hydrochloric Acid → 1-(2-Chloropyridin-4-yl)ethan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 2-Chloro-4-cyanopyridine | HCID 568638 | — |
| 反応物 | HCID 178418332 | HCID 178418332 | — |
| 生成物 | 1-(2-Chloropyridin-4-yl)ethan-1-one | HCID 13145255 | — |
反応手順
24.61 g (177.62 mmol) of 2-chloro-4-cyano-pyridine are placed in 1.25 litres of diethyl ether under nitrogen, and 120 ml (22% in tetrahydrofuran, 353 mmol) of methyl-magnesium chloride are added. The red suspension is stirred for 40 h at RT, poured onto 1.25 litres of ice/water and 250 ml of 6N HCl and stirred for 14 h at RT. Extraction with diethyl ether and methylene chloride, drying with MgSO4 and concentration give 4-acetyl-2-chloro-pyridine; Rf =0.5 (methylene chloride:methanol=9:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728708 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-160c9a75cc8c48d189fa78e2f7af0bda |
| 出典メモ | uspto-grants-1998_03 |