Water → Methyl [o-(5-fluoro-2-nitrophenoxy)phenoxy]acetate

HRID 21521

反応式

HRID 21521 の反応式
Br[CH2:2][C:3]([O:5][CH3:6])=[O:4].[F:7][C:8]1[CH:9]=[CH:10][C:11]([N+:22]([O-:24])=[O:23])=[C:12]([CH:21]=1)[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[OH:20].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[F:7][C:8]1[CH:9]=[CH:10][C:11]([N+:22]([O-:24])=[O:23])=[C:12]([CH:21]=1)[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH2:2][C:3]([O:5][CH3:6])=[O:4]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 19932387o-(5-Fluoro-2-nitrophenoxy)phenol

生成物 1

HCID 54233795Methyl [o-(5-fluoro-2-nitrophenoxy)phenoxy]acetate収率 81.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Methyl bromoacetate (36.33 g, 0.24 mol) is added to a mixture of o-(5-fluoro-2-nitrophenoxy)phenol (39.45 g, 0.16 mol) and potassium carbonate (32.75 g, 0.24 mol) in N,N-dimethylformamide. The reaction mixture is stirred at room temperature for 18 hours, poured into water and extracted with ether. The organic extract is washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo to obtain the title product as a yellow solid (42 g) which is identified by 1HNMR spectral analysis.

後処理

  1. extractionextracted with ether
  2. extractionThe organic extract
  3. washis washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-d2eaa8cd6bf449bc8dcd66174c984ef3
出典データセット
uspto-grants-1995_06
特許番号
US05424280

関連ノート

読み込み中…