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2-Chloro-3-nitropyridine → N-(3-nitro-2-pyridyl)-(-)-S-methyl-L-cysteine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| 反応物 | Methyl (2R)-2-amino-3-(methylsulfanyl)propanoate | HCID 1277655 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | N-(3-nitro-2-pyridyl)-(-)-S-methyl-L-cysteine methyl ester | HCID 22853894 | 54.1% |
反応手順
In analogy to Example 2, but using only one mole equivalent of triethylamine, 5 g (27 mmol) of (-)-S-methyl-L-cysteine methyl ester were reacted with 3.51 g (22.5 mmol) of 2-chloro-3-nitropyridine (reaction conditions: 5 hours at 80° C.). Working up was followed by chromatography on silica gel (n-heptane/acetone/methyl t-butyl ether=5:1:1). 3.3 g (45%) of N-(3-nitro-2-pyridyl)-(-)-S-methyl-L-cysteine methyl ester, of melting point 95°-97° C., were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424311 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-68f2246ec70343a2bb4deaa94940cc63 |
| 出典メモ | uspto-grants-1995_06 |