化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 3(R,S)-Phenyl-3,4-dihydro-1,4,5-triazanaphthalen-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| 反応物 | Methyl phenylglycinate, L- | HCID 1201451 | — |
| 溶媒 | n-Heptane acetone methyl t-butyl ether | HCID 131719020 | — |
| 生成物 | 3(R,S)-Phenyl-3,4-dihydro-1,4,5-triazanaphthalen-2(1H)-one | HCID 12238423 | — |
反応手順
In analogy to Example 2, but using only one mole equivalent of triethylamine, 4.45 g (27 mmol) of D/L-phenylglycine methyl ester were reacted with 3.51 g (22 mmol) of 2-chloro-3-nitropyridine. Working up and column chromatography (n-heptane/acetone/methyl t-butyl ether=5:1:1) resulted in 3.27 g (42%) of N-(3-nitro-2-pyridyl)-(D/L)-phenylglycine methyl ester of melting point 70° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424311 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-f34fac4c8ee24d50b5e8661561835b8e |
| 出典メモ | uspto-grants-1995_06 |