N-(2-Methoxy-phenyl)-malonamic acid → N1-(3-fluoro-4-(2-(1-propyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-(2-methoxyphenyl)malonamide

反応式

[CH3:41][O:42][c:43]1[c:44]([NH:49][C:50]([CH2:51][C:52](=[O:53])[OH:54])=[O:55])[cH:45][cH:46][cH:47][cH:48]1.[F:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][cH:7][c:8]1[O:9][c:10]1[c:11]2[c:12]([n:13][cH:14][cH:15]1)[cH:16][c:17](-[c:19]1[n:20][cH:21][n:22]([CH2:24][CH2:25][CH3:26])[cH:23]1)[s:18]2.[F:27][c:28]1[cH:29][cH:30][cH:31][cH:32][c:33]1[NH:34][C:35](=[O:36])[CH2:37][C:38]([OH:39])=[O:40]>>[F:1][c:2]1[cH:3][c:4]([NH:5][C:52]([CH2:51][C:50]([NH:49][c:44]2[c:43]([O:42][CH3:41])[cH:48][cH:47][cH:46][cH:45]2)=[O:55])=[O:53])[cH:6][cH:7][c:8]1[O:9][c:10]1[c:11]2[c:12]([n:13][cH:14][cH:15]1)[cH:16][c:17](-[c:19]1[n:20][cH:21][n:22]([CH2:24][CH2:25][CH3:26])[cH:23]1)[s:18]2