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Dimethylformamide diethylacetal → 3-Dimethylamino-1-(2-chloro4-pyridyl)-2-propen-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide diethylacetal | HCID 70913 | — |
| 反応物 | 1-(2-Chloropyridin-4-yl)ethan-1-one | HCID 13145255 | — |
| 生成物 | 3-Dimethylamino-1-(2-chloro4-pyridyl)-2-propen-1-one | HCID 54435039 | — |
反応手順
16.2 g (104.2 mmol) of 4-acetyl-2-chloro-pyridine are stirred at 110° with 116 ml of dimethylformamide diethylacetal for 1 h. Cooling to 0°, filtering and drying at 60° under HV give 3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one; 1H-NMR (dimethyl sulfoxide): 2.98 (3H,s), 3.2 (3H,s), 5.9 (1H,d), 7.8 (3H,m), 8.5 (1H
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728708 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-17f4a6bed6804e1a87ae17bb1cfb5ad3 |
| 出典メモ | uspto-grants-1998_03 |