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p-Toluenesulfonic acid → 2-[(3-Bromophenyl)methoxy]oxane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | 3-Bromobenzyl alcohol | HCID 85141 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-[(3-Bromophenyl)methoxy]oxane | HCID 15282064 | — |
反応手順
A solution of 3-bromobenzyl alcohol (84.9 g; Aldrich), 3,4-dihydro-2H-pyran (44 g) and anhydrous p-toluene sulfonic acid (1 g) in CH2Cl2 (800 mL) was stirred at 5° C. for 1 hr. then at r.t. overnight. The mixture was concentrated and the residue chromatographed (5% EtOAc/hexane) to afford the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424320 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-2db09be680da427fb5198d935bceca3f |
| 出典メモ | uspto-grants-1995_06 |