2,6-Dimethyl-4-pyranone → Tetrahydro-2,6-dimethyl-4H-pyran-4-one

HRID 21561

反応式

HRID 21561 の反応式
[CH3:1][C:2]1[O:8][C:7]([CH3:9])=[CH:6][C:4](=[O:5])[CH:3]=1>CCO>[CH3:9][CH:7]1[CH2:6][C:4](=[O:5])[CH2:3][CH:2]([CH3:1])[O:8]1

参加物

3

反応物 1

HCID 138622,6-Dimethyl-4-pyranone

生成物 1

HCID 70626Tetrahydro-2,6-dimethyl-4H-pyran-4-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2,6-dimethyl-γ-pyrone (17 g, Aldrich) in EtOH 95% (300 mL) was hydrogenated for 3 days under 70 psi. After filtration over celite, the solvent was evaporated and replaced by CH2Cl2. The solution was then treated with celite (30 g) and PCC (48.5 g). The suspension was stirred for 3 hr. and the reaction was diluted with Et2O (300 mL) and then filtered over a pad of celite. The filtrate was evaporated to dryness and the residual solution was then chromatographed using hexane/Et2O (1:1) to give the title compound.

後処理

  1. filtrationAfter filtration over celite
  2. customthe solvent was evaporated
  3. additionThe solution was then treated with celite (30 g) and PCC (48.5 g)
  4. additionand the reaction was diluted with Et2O (300 mL)
  5. filtrationfiltered over a pad of celite
  6. customThe filtrate was evaporated to dryness
  7. customthe residual solution was then chromatographed

出典と根拠

ORDレコード
ord-5f26eb2c965e46b1b3e67610bca06f60
出典データセット
uspto-grants-1995_06
特許番号
US05424320

関連ノート

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