2-Chloroethyl Isothiocyanate → HCID 68954103、化合物

HRID 215708

反応式

HRID 215708 の反応式
[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].Cl[CH2:12][CH2:13][N:14]=[C:15]=[S:16]>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:15]1[S:16][CH2:12][CH2:13][N:14]=1

参加物

4

反応物 2

HCID 1386612-Chloroethyl IsothiocyanateHCID 5876252,3-Dichlorobenzylamine

生成物 1

HCID 68954103HCID 68954103、化合物収率 163.2%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
80 °C

実験手順

A mixture of 0.5 gram (0.0028 mole) of 2,3-dichlorobenzylamine and 0.27 gram (0.0081 mole) of 2-chloroethylisothiocyanate in 10 mL of 1,4-dioxane was placed in a sealed reaction vial. The reaction mixture was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 0.68 gram of the title compound. The NMR spectrum was consistent with the proposed structure.

後処理

  1. customwas placed in a sealed reaction vial
  2. temperatureto cool
  3. customa solid precipitate that had formed
  4. filtrationwas collected by filtration
  5. washThe solid was rinsed with diethyl ether
  6. customwas dried under reduced pressure

出典と根拠

ORDレコード
ord-6d25758682194a3e9cb055f2726f3e52
出典データセット
uspto-grants-2012_06
特許番号
US08193118B2

関連ノート

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