関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Resorcinol | HCID 5054 | — |
| 反応物 | Ethyl benzoylacetate | HCID 7170 | — |
| 溶媒 | Phosphoric Acid | HCID 1004 | — |
| 生成物 | 7-Hydroxy-4-phenylcoumarin | HCID 5357479 | — |
反応手順
A mixture of resorcinol (20 g), ethyl benzoylacetate (23.8 mL) and O-phosphoric acid (130 mL) was heated at 85° C. (care!) for 1 hr. The solution was cooled, poured onto H2O, extracted 3×EtOAc/THF, washed twice with H2O, and then twice with brine. The organic phase was dried and evaporated. Trituration with Et2O followed by filtration afforded the title compound as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05424320 |
|---|
| 出典データセット | uspto-grants-1995_06 |
|---|
| ORD ID | ord-676f55a760bb46bcbae02c9496dfc607 |
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| 出典メモ | uspto-grants-1995_06 |
|---|
