2-Chloroethyl Isothiocyanate → ((2,3-Dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

HRID 215710

反応式

HRID 215710 の反応式
[CH3:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].[Cl:11][CH2:12][CH2:13][N:14]=[C:15]=[S:16]>O1CCOCC1>[ClH:11].[CH3:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:15]1[S:16][CH2:12][CH2:13][N:14]=1

参加物

4

反応物 2

HCID 1386612-Chloroethyl IsothiocyanateHCID 2800811(2,3-Dimethylphenyl)methanamine

生成物 1

HCID 68955163((2,3-Dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride収率 76%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
80 °C

実験手順

Under a dry nitrogen atmosphere, a stirred mixture of 5.56 grams (0.041 mole) of 2,3-dimethylbenzylamine and 5.0 grams (0.041 mole) of 2-chloroethylisothiocyanate in 100 mL of 1,4-dioxane was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 8.0 grams of the title compound. The NMR spectrum was consistent with the proposed structure.

後処理

  1. temperatureto cool
  2. customa solid precipitate that had formed
  3. filtrationwas collected by filtration
  4. washThe solid was rinsed with diethyl ether
  5. customwas dried under reduced pressure

出典と根拠

ORDレコード
ord-ab661d7a8bcc4d6ba081a13baa6c3320
出典データセット
uspto-grants-2012_06
特許番号
US08193118B2

関連ノート

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