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Carbon Tetrachloride → 7-Chloromethyl-4-(3-thienyl)coumarin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbon Tetrachloride | HCID 5943 | — |
| 反応物 | Hexamethylphosphorous triamide | HCID 15355 | — |
| 反応物 | 7-Hydroxymethyl-4-(3-thienyl)coumarin | HCID 15780558 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 7-Chloromethyl-4-(3-thienyl)coumarin | HCID 15780559 | — |
反応手順
To a solution of the alcohol from Step 1 (1.65 g) and hexamethylphosphorous triamide in 35 mL THF at 0° C. was added CCl4 (1.3 mL) and the mixture stirred for 30 min. The mixture was diluted with Et2O, filtered, concentrated and the residue chromatographed (30% EtOAc/hexane) to provide the title compound as a solid, m.p. 125°-127° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424320 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-41bf4b14ae7e4194a8b652aa27b29dc4 |
| 出典メモ | uspto-grants-1995_06 |