Methylamine → N,1-Dimethyl-5-methoxy-3-(1-methylethoxy)-1H-indole-2-carboxamide

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7]([C:13](O)=[O:14])=[C:6]2[O:16][CH:17]([CH3:19])[CH3:18].[CH3:20][NH2:21].[OH-].[NH4+]>>[CH3:20][NH:21][C:13]([C:7]1[N:8]([CH3:12])[C:9]2[C:5]([C:6]=1[O:16][CH:17]([CH3:19])[CH3:18])=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2)=[O:14]

参加物

反応物 3

HCID 6329Methylamine

HCID 14923Ammonium Hydroxide

HCID 138857995-Methoxy--methyl-3-(1-methylethoxy)-1H-indole-2-carboxylic acid

生成物 1

HCID 19933216N,1-Dimethyl-5-methoxy-3-(1-methylethoxy)-1H-indole-2-carboxamide収率 45%

実験手順

Prepared from 5-methoxy-1-methyl-3-(1-methylethoxy)-1H-indole-2-carboxylic acid by the procedure of Example 1 with 40% aqueous methylamine solution substituted for ammonium hydroxide. Yield 45% after recrystallization from hexane; mp 85°-86° C.