N-allyl-5-azaisatin → 1H-Pyrrolo[3,2-c]pyridine-2,3-dione

HRID 215792ノート

反応式

HRID 215792 の反応式
C([N:4]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[C:7](=[O:8])[C:5]1=[O:6])C=C>C1(C)C=CC=CC=1>[NH:4]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[C:7](=[O:8])[C:5]1=[O:6]

参加物

3

反応物 1

HCID 19390720N-allyl-5-azaisatin

生成物 1

HCID 107019651H-Pyrrolo[3,2-c]pyridine-2,3-dione

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of N-allyl-5-azaisatin (5.3 mmol), (Ph3P)3RhCl (0.5 mmol) in aqueous toluene is stirred under a nitrogen atmosphere at room temperature overnight. The organic layer is dried (MgSO4) and the solvent is evaporated. The residue is stirred in 1N HCl/MeOH for 15 min after which time the methanol is evaporated and the pH of the water is adjusted to 7. A precipitate is formed and purified by silica gel chromatography (1% MeOH:CHCl3) to obtain the title compound.

後処理

  1. dry with materialThe organic layer is dried (MgSO4)
  2. customthe solvent is evaporated
  3. customis evaporated
  4. customA precipitate is formed
  5. custompurified by silica gel chromatography (1% MeOH:CHCl3)

出典と根拠

ORDレコード
ord-1b821936825e4bb88acc22bd5f8f91ee
出典データセット
uspto-grants-2012_06
特許番号
US08193185B2

反応ノート

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