N-{(1S,2R,3S,4R)-4-[2-((R)-3-Amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide dihydrochloride → N-{(1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

HRID 215894ノート

反応式

HRID 215894 の反応式
Cl.Cl.[NH2:3][C@@H:4]1[CH2:8][CH2:7][N:6]([C:9]2[N:17]=[C:16]3[C:12]([N:13]=[CH:14][N:15]3[C@@H:18]3[CH2:22][C@H:21]([NH:23][C:24](=[O:27])[CH2:25][CH3:26])[C@@H:20]([OH:28])[C@H:19]3[OH:29])=[C:11]([NH:30][CH2:31][CH:32]([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:10]=2)[CH2:5]1>C(O)C>[NH2:3][C@@H:4]1[CH2:8][CH2:7][N:6]([C:9]2[N:17]=[C:16]3[C:12]([N:13]=[CH:14][N:15]3[C@@H:18]3[CH2:22][C@H:21]([NH:23][C:24](=[O:27])[CH2:25][CH3:26])[C@@H:20]([OH:28])[C@H:19]3[OH:29])=[C:11]([NH:30][CH2:31][CH:32]([C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=3)[C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[N:10]=2)[CH2:5]1

参加物

3

反応物 1

HCID 67022955N-{(1S,2R,3S,4R)-4-[2-((R)-3-Amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide dihydrochloride

生成物 1

HCID 59781437N-{(1S,2R,3S,4R)-4-[2-((R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

N-{(1S,2R,3S,4R)-4-[2-((R)-3-Amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide dihydrochloride (ca. 7.7 mmol) is dissolved in minimal volume of a mixture of ethanol/saturated aqueous sodium carbonate solution until the pH of the solution is adjusted to pH 7 (ensuring the compound remains in solution). The solution is loaded onto an Isolute™ C18 column and washed through firstly with water and then MeOH. The fractions are combined and concentrated in vacuo and then further purified by repeating the above process to afford the title compound. LCMS (electrospray): m/z [MH+] 571

後処理

  1. washwashed through firstly with water
  2. concentrationconcentrated in vacuo
  3. customfurther purified

出典と根拠

ORDレコード
ord-b5299e0c8fbe4c7f8b8a4fdca4170803
出典データセット
uspto-grants-2012_06
特許番号
US08193164B2

反応ノート

読み込み中…