3-(Dimethylamino)phenol → HCID 58006189、化合物

HRID 215913

反応式

HRID 215913 の反応式
[CH3:1][N:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[CH:5]=1)[CH3:3].Cl[CH2:12][C:13]([N:15]([CH3:17])[CH3:16])=[O:14].C([O-])([O-])=O.[K+].[K+]>CS(C)=O.ClCCl>[CH3:1][N:2]([CH3:3])[C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:12][C:13]([N:15]([CH3:17])[CH3:16])=[O:14]

参加物

6

反応物 3

HCID 74213-(Dimethylamino)phenolHCID 11430Potassium CarbonateHCID 758862-chloro-N,N-dimethylacetamide

生成物 1

HCID 58006189HCID 58006189、化合物

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 6344Dichloromethane溶媒

実験手順

To a mixture of 3-N,N-dimethylamino phenol (69) (3.43 g, 25 mmol) and 2-chloro N,N-dimethylacetamide (3.66 g, 30 mmol) in DMSO (30 mL) was added K2CO3 (6.7 g, 50 mmol) and the resulting suspension was stirred at room temperature for 16 h. The reaction was then diluted with dichloromethane (125 mL), and washed with water (2×100 mL), and brine (100 mL), and dried, and filtered, and the solvent was removed under vacuum. The crude product, Compound 70, was obtained as purple, thick oil that was used in the next step without additional purification.

後処理

  1. washwashed with water (2×100 mL), and brine (100 mL)
  2. customdried
  3. filtrationfiltered
  4. customthe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-8c0bde69592943d7a6750f0b57894054
出典データセット
uspto-grants-2012_06
特許番号
US08193203B2

関連ノート

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