Isopropyl iodide → 3-Isopropoxy-N,N-dimethylaniline

HRID 215928

反応式

HRID 215928 の反応式
[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.C([O-])([O-])=O.[K+].[K+].I[CH:18]([CH3:20])[CH3:19]>CC(C)=O>[CH:18]([O:9][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=1)[N:2]([CH3:10])[CH3:1])([CH3:20])[CH3:19]

参加物

5

反応物 3

HCID 6362Isopropyl iodideHCID 74213-(Dimethylamino)phenolHCID 11430Potassium Carbonate

生成物 1

HCID 580062633-Isopropoxy-N,N-dimethylaniline

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 3-(dimethylamino)phenol (2.0 g, 14.60 mmol) in acetone (40.0 mL) were added K2CO3 (20.2 g, 146.0 mmol) and 2-iodopropane (2.20 mL, 21.90 mmol), and the reaction was refluxed for 18 h, then cooled to room temperature, and filtered through Celite. The solvent was removed under vacuum, and the residue was purified by silica gel chromatography using ethyl acetate (20%) and hexanes (80%) as eluent to produce Compound 135 as yellow oil.

後処理

  1. temperaturethe reaction was refluxed for 18 h
  2. filtrationfiltered through Celite
  3. customThe solvent was removed under vacuum
  4. customthe residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-56a13a33a481464abc3dc54c25c3545e
出典データセット
uspto-grants-2012_06
特許番号
US08193203B2

関連ノート

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