Lithium amide → 1-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide

HRID 21595

反応式

HRID 21595 の反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:8][CH:9]=2)[C:4]([S:19][CH:20]([CH3:22])[CH3:21])=[C:3]1[C:23]([O:25]CC)=O.[NH2-:28].[Li+]>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:8][CH:9]=2)[C:4]([S:19][CH:20]([CH3:22])[CH3:21])=[C:3]1[C:23]([NH2:28])=[O:25]

参加物

3

反応物 2

HCID 24532Lithium amideHCID 15294535ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate

生成物 1

HCID 152945321-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide収率 78%

実験手順

Prepared from ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate and lithium amide as described in Example 18. After evaporation of excess ammonia, the residue is treated with ice water. The insoluble material is filtered and washed with water, then recrystallized from ethyl acetate-hexane. Yield 78%; mp 151°-154° C.

後処理

  1. customAfter evaporation of excess ammonia
  2. additionthe residue is treated with ice water
  3. filtrationThe insoluble material is filtered
  4. washwashed with water
  5. customrecrystallized from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-a14145a8404a40248665186c7668a3e0
出典データセット
uspto-grants-1995_06
特許番号
US05424329

関連ノート

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