化工社化工社 化学情報印刷レポート · 研究参考用
HCID 178525099、化合物 → HCID 178517869、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | HCID 178525099 | HCID 178525099 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178517869 | HCID 178517869 | 93% |
反応手順
200 mg of Pd/C was added a solution of benzyl 2-(trans-4-hydroxycyclohexyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate (2.13 g, 0.00551 mol) in methanol (50 mL) under nitrogen. The reaction mixture was stirred under an atmosphere of hydrogen for 3 hrs. The mixture was filtered, and the filtrate was concentrated to give 2-(trans-4-hydroxycyclohexyl)-2,8-diazaspiro[4.5]decan-1-one (1.29 g, 93%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08193207B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-5c1a45a98225417ebd086aeb9deb2126 |
| 出典メモ | uspto-grants-2012_06 |