Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide → Imidazo[1,2-a]pyridin-2(3H)-one hydrobromide

HRID 215965ノート

反応式

HRID 215965 の反応式
[BrH:1].C([O:4][C:5](=O)[CH2:6][N:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=[NH:13])C>C(O)C>[BrH:1].[N:13]1[C:5](=[O:4])[CH2:6][N:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12

参加物

3

反応物 1

HCID 68699194Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

生成物 1

HCID 44121307Imidazo[1,2-a]pyridin-2(3H)-one hydrobromide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 9 g (34.4 mmol) of (2-imino-2H-pyridin-1-yl)-acetic acid ethyl ester hydrobromide salt in 200 mL of ethanol is heated at reflux for 18 h. The reaction mixture is then cooled to room temperature and the precipitate is collected. The isolated solid is washed with ethanol to give the desired compound.

後処理

  1. temperatureat reflux for 18 h
  2. customthe precipitate is collected
  3. washThe isolated solid is washed with ethanol

出典と根拠

ORDレコード
ord-4312b25132944418ae79d67d6590fecd
出典データセット
uspto-grants-2012_06
特許番号
US08193214B2

反応ノート

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