1-Naphthaldehyde → 3-[1-Naphthalen-1-yl-methylidene]-imidazo[1,2-a]pyridin-2-one

HRID 215966ノート

反応式

HRID 215966 の反応式
Br.[N:2]1[C:3](=[O:11])[CH2:4][N:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12.[C:12]1([CH:22]=O)[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1>C(O)C>[C:12]1([CH:22]=[C:4]2[N:5]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]3=[N:2][C:3]2=[O:11])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 61951-NaphthaldehydeHCID 44121307Imidazo[1,2-a]pyridin-2(3H)-one hydrobromide

生成物 1

HCID 686995473-[1-Naphthalen-1-yl-methylidene]-imidazo[1,2-a]pyridin-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1 g (4.7 mmol) of imidazo[1,2-a]pyridin-2-one hydrobromide salt and 726 mg (4.7 mmol) of 1-naphthaldehyde in 20 mL of ethanol is heated at reflux for 1 h and then cooled to room temperature. The precipitate is collected. The isolated solid is suspended in 40 mL of 2M potassium carbonate solution and the resulting mixture is stirred for 48 h at room temperature. The precipitated solid is collected and washed with water to give the desired compound.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 1 h
  3. customThe precipitate is collected
  4. customThe precipitated solid is collected
  5. washwashed with water

出典と根拠

ORDレコード
ord-f0f06ba9212746fab22dcc4750bb68b5
出典データセット
uspto-grants-2012_06
特許番号
US08193214B2

反応ノート

読み込み中…