1H-Indole-2-carboxylic acid, 1-methyl-5-(phenylmethoxy)-, ethyl ester → Ethyl 5-hydroxy-1-methyl-1H-indole-2-carboxylate
反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11]CC3C=CC=CC=3)=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:19]([O:21][CH2:22][CH3:23])=[O:20]>C(O)C>[OH:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:2]([CH3:1])[C:3]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:4]2参加物
3
実験手順
Prepared from ethyl 1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate (Monge Vega A, et al., An. Ouim. 72:267) by catalytic hydrogenolysis in ethanol as described in Example 15. Recrystallization from ether gives the product in 80% yield; mp 140°-142° C.
後処理
- customRecrystallization from ether
- customgives the product in 80% yield
出典と根拠
- ORDレコード
- ord-ba46a826d6e6487bac0d0fa08f6fa94b
- 出典データセット
- uspto-grants-1995_06
- 特許番号
- US05424329
反応ノート
読み込み中…