Imidazo[1,2-a]pyridin-2(3H)-one hydrobromide → 3-(4-Methyl-benzo[b]thiophen-3-ylmethylene)-imidazo[1,2-a]pyridin-2-one

HRID 215971ノート

反応式

HRID 215971 の反応式
Br.[N:2]1[C:3](=[O:11])[CH2:4][N:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12.[CH3:12][C:13]1[C:21]2[C:20]([CH:22]=O)=[CH:19][S:18][C:17]=2[CH:16]=[CH:15][CH:14]=1>C(O)C>[CH3:12][C:13]1[C:21]2[C:20]([CH:22]=[C:4]3[N:5]4[CH:10]=[CH:9][CH:8]=[CH:7][C:6]4=[N:2][C:3]3=[O:11])=[CH:19][S:18][C:17]=2[CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 44121307Imidazo[1,2-a]pyridin-2(3H)-one hydrobromideHCID 579956704-Methyl-benzo[b]thiophene-3-carbaldehyde

生成物 1

HCID 686997973-(4-Methyl-benzo[b]thiophen-3-ylmethylene)-imidazo[1,2-a]pyridin-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1.6 g (7.4 mmol) of imidazo[1,2-a]pyridin-2-one hydrobromide salt and 1.2 g (6.7 mmol) of 4-methyl-benzo[b]thiophene-3-carbaldehyde in 40 mL of ethanol is heated at reflux for 1 h and then cooled to room temperature. The precipitate is collected. The isolated solid is suspended in 40 mL of 2M potassium carbonate solution and the resulting mixture is stirred for 48 h at room temperature. The solid is collected and washed with water to give the desired compound.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 1 h
  3. customThe precipitate is collected
  4. customThe solid is collected
  5. washwashed with water

出典と根拠

ORDレコード
ord-c87e87eadcd744539f716a1f867b5e61
出典データセット
uspto-grants-2012_06
特許番号
US08193214B2

反応ノート

読み込み中…