Ethanol → 4-Phenylthiophen-2-amine
反応式
C(OC([C:6]1[C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:9][S:8][C:7]=1[NH2:17])=O)C.C(O)C>[OH-].[K+].O>[C:11]1([C:10]2[CH:6]=[C:7]([NH2:17])[S:8][CH:9]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1参加物
5
実験手順
2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester (5 g, 20.2 mmol) was suspended in 20% potassium hydroxide solution (100 ml) and heated to reflux. Ethanol (100 ml) was added to aid dissolution. The reaction was stirred overnight and then cooled to room temperature and diluted with water (250 ml). The precipitated solid was collected by filtration and dissolved in DCM/ethyl acetate before drying over magnesium sulfate. The solvent was removed in vacuo to give 4-phenyl-thiophen-2-ylamine. Yield 1.05 g (30%).
後処理
- temperatureheated to reflux
- filtrationThe precipitated solid was collected by filtration
- dissolutiondissolved in DCM/ethyl acetate
- dry with materialbefore drying over magnesium sulfate
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-a73fe8223e3b4f90ba905d3133e4161a
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08193215B2
反応ノート
読み込み中…