N-Bromoacetamide → 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

HRID 216023

反応式

HRID 216023 の反応式
[Cl:1][C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[Br:11]NC(=O)C>C(Cl)Cl>[Br:11][C:10]1[C:3]2[C:2]([Cl:1])=[N:7][CH:6]=[N:5][C:4]=2[NH:8][CH:9]=1

参加物

4

反応物 2

HCID 4353N-BromoacetamideHCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-

生成物 1

HCID 53807105-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine収率 82%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1.2 g, 7.8 mmol) in CH2Cl2 (25 mL) was added N-bromoacetamide (1.2 g, 8.7 mmol) in CH2Cl2 (25 mL). The reaction mixture was refluxed for 40 minutes, then concentrated and washed with cold water. The crude material was recrystallized from a minimal amount of isopropanol and dried under vacuum to give the title compound (82%) as light-gray solid. MS (ES+) [M+H]+=232.

後処理

  1. temperatureThe reaction mixture was refluxed for 40 minutes
  2. concentrationconcentrated
  3. washwashed with cold water
  4. customThe crude material was recrystallized from a minimal amount of isopropanol
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-fd79b2c07845414fba0e4c6477f390a4
出典データセット
uspto-grants-2012_06
特許番号
US08193202B2

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