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Hydrochloric Acid → 4-Phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-((Tert-butoxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid | HCID 736917 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-Phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid | HCID 19259 | 109.3% |
反応手順
1-(tert-Butoxycarbonyl)-4-phenylpiperidine-4-carboxylic acid (1.0 g, 3.3 mmol) was treated with 4 N HCl in dioxane (20 mL) for 2 hours at room temperature. The product was isolated by filtration to provide the title compound (0.74 g, 93%) as a white solid. MS (ES+) [M+H]+=206.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08193202B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-1df7985a55a04ddfa276f21ffbc22a18 |
| 出典メモ | uspto-grants-2012_06 |