Hydrochloric Acid → N-(3-tert-butylphenyl)-4-methylpiperidine-4-carboxamide

HRID 216037

反応式

HRID 216037 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]([C:14]2([CH3:27])[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)=[O:13])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Cl>CO>[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]([C:14]2([CH3:27])[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)=[O:13])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86635224HCID 86635224、化合物

生成物 1

HCID 67036907N-(3-tert-butylphenyl)-4-methylpiperidine-4-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

tert-Butyl 4-(3-tert-butylphenylcarbamoyl)-4-methylpiperidine-1-carboxylate from step A (0.4 g, 1.07 mmol) was treated with HCl (4.0 N in dioxane, 1.3 mL, 5.34 mmol) in methanol (5.0 mL) at 50° C. for 30 minutes. The mixture was concentrated to give the title compound as the hydrochloride salt in quantitative yield. MS (ES+) [M+H]+=275.

後処理

  1. concentrationThe mixture was concentrated

出典と根拠

ORDレコード
ord-361d2af2da5940e2b12b405634062e3a
出典データセット
uspto-grants-2012_06
特許番号
US08193202B2

関連ノート

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